Editorial Board
Salvatore Papa
Leeds Institute of Cancer and Pathology, Faculty of Medicine and Health, University of Leeds · United Kingdom
Editorial leadership for Journal of Hematology and Oncology Research ISSN 2372-6601
Research interests
- Cancer Metabolism; Apoptosis; Signalling Pathways; Mitogen-Activated Protein Kinase (Mapk); C-Jun N-Terminal Kinase (Jnk); Nf-Kappa B Transcription Factor
Biography
- My current research programs focus on understanding basic cellular mechanisms (i.e. DNA transcription and protein post translational modifications), molecules that control complex regulatory pathways (signal transduction, gene regulation, development and differentiation), and the molecular basis for immunity, inflammation and cancer.
- The serine/threonine c-Jun-N-terminal kinase (JNK) is an important signalling pathway in eukaryotic cells, and has been chosen as model system to investigate the mechanisms of signal transduction.
- JNK responds to a variety of extracellular stimuli and regulates various cellular events, including the induction of apoptosis induced by reactive oxygen species (ROS), cell proliferation, and resistance to apoptosis.
- Consistent with the importance of these events in inflammation and tumorigenesis, regulation of JNK signalling is associated with immunity and cancers in humans.
- JNK1 and JNK2 are the major forms of JNK expressed ubiquitously.
- The paradigm is that both JNK1 and JNK2 contribute at the same cellular function.
- However, emerging evidence from our and other studies demonstrate that JNK1 and JNK2 have either distinct or even opposing biological functions, especially in cancer development (Barbarulo et al., Oncogene 2013; Bubici and Papa, Br J Pharmacol 2014).
- In a recent study published in Nature Communications (Iansante et al., Nat Commun 2015) we demonstrated that cancer cells stimulate the over-production of the protein known as PARP14, which enable cancer cells to use glucose to turbocharge their growth and override the natural check of cell death.
- Using a combination of genetic and molecular biology approaches, we have also uncovered an intricate link between JNK and cellular metabolism, providing evidence for JNK regulating an inextricable crosstalk between apoptosis and metabolism (Papa S, Bubici C, Mol Cell Oncol 2016)
Selected publications
- The ERK and JNK pathways in the regulation of metabolic reprogramming 2018 cited 336×
- Thyroid hormone in the regulation of hepatocellular carcinoma and its microenvironment 2018 cited 23×
- Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth 2021 cited 19×
- Feeding the Hedgehog: A new meaning for JNK signalling in liver regeneration 2018 cited 10×
- Osteopontin Promotes Cholangiocyte Secretion of Chemokines to Support Macrophage Recruitment and Fibrosis in MASH 2024 cited 10×
- ASKing No More: The Emerging Role of Dual‐Specific Phosphatase 12 in the Regulation of Hepatic Lipid Metabolism 2019 cited 2×
Ranked by citation impact (Crossref) where available, newest otherwise · verified via ORCID.
Considering JHOR for your work?
This journal is guided by Salvatore Papa (Leeds Institute of Cancer and Pathology, Faculty of Medicine and Health, University of Leeds) and a peer-review board of practising researchers. Open access, author-retained copyright (CC BY), and a clear editorial process.