All Articles

Thyroid Function Abnormalities in Patients with Chronic Kidney Disease

Abstract:

The function of the thyroid gland is one of the most important in the human body as it regulates the majority of the body's physiological actions. The thyroid produces hormones (T3 and T4) that have many actions including metabolism, development, protein synthesis, and the regulation of many other important hormones. There is a lot of interaction between the kidney and thyroid gland during the disease States thyroid hormones have a major role in regulating the glomerular filtration rate through its hormonal actions in normal physiology. But these things are altered in the disease States such as chronic kidney disease. It is a well-known fact that hypothyroidism causes decreased Glomerular filtration rate whereas hyperthyroidism causes increased Glomerular filtration rate leading to renin-angiotensin-aldosterone system activation. In our study we aim to see the prevalence of low T3 syndrome in different stages of CKD which is a state of physiologic...

Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryo during Organogenesis and their Role as Epigenetics Regulators able to Reverse Neurosensory Hearing Loss

Abstract:

This translational paper discusses differentiation‑stage factors from zebrafish embryos as epigenetic regulators with potential to reverse neurosensory hearing loss. It outlines experimental evidence, delivery concepts, and research gaps.

Functional State Hardware Evaluation System in Educational Medium

Abstract:

Diagnosis of heart rate variability as an indicator of the impact of external and internal media can serve to make changes in the educational environment. The approach to the organization of the educational process is developed on the basis of quantitative indicators of the students’ functional state using the hardware-software complex " Varikard ".

Iodometric Determination of Neutral Amino Acids Using Potassium Iodate

Abstract:

In this work, we have reported a simple, cost effective and reliable method for the determination of neutral α-amino acids iodometrically by making use of potassium iodate. This volumetric method determines amino acids instantly, thereby greatly reduces the time of determination.

Clinical Use of Peptide-Based Formula (Peptamen Junior®, Nestle) in the Paediatric Population

Abstract:

There is limited published data describing the characteristics of the paediatric population prescribed semi elemental formulas. This retrospective observational audit aimed to describe the characteristics of the paediatric patients who have been prescribed a hydrolysed whey protein, medium chain triglycerides (MCT) based formula, Peptamen Junior® and the nutritional outcomes.

Removal of Neutral Red from Aqueous solutions usingSr2CaBO5.5 (B= Nb+5& Ta+5)

Abstract:

Two samples of the defectdouble perovskites with general formula Sr₂CaNbO_5.5 and Sr₂CaTaO_5.5 were synthesized and their cap abilities in the removal of neutral red dye investigated. Both samples have faced cubic perovskite-type structure in space group Fm3m. The replacement of Nb⁵⁺ by Ta⁵⁺ has influenced both crystal size and density of the two oxides but showed no impact on the removal capacities. The crystallite size of Sr₂CaNbO_5.5 and Sr₂CaTaO_5.5 was determined to be 93.56 and 43.69 nm respectively. The maximum removal capacities of Neutral red are found to be 190.5 mg/g using both the two oxides. This result is consistent with the cell volumes which displayed similar values. The removal of Neutral Red has a negative relationship with temperature but steadily increases as pH increased.

Inferior Turbinate Surgery: Difficulties Between the Decision-Making and the Selection of Proper Technique

Abstract:

The inferior conchae have important role in the maintenance of nasal airflow via providing the nasal valve mechanism but increase of inferior turbinate bulk may result in significant nasal obstruction. Therefore, this may need further surgical intervention to deal with these bulky conchae but it is very necessary to balance between the mechanical as well as the functional patency of the nose. Thus, through this surgery it become difficult to decide whether the patient is a candidate for surgery and which technique is suitable for that particular patient.

Principles and Constants of the Golden Proportion as a Criterion in Donosological Diagnostics of the Functional States of The Body and in the Assessment of the Probability of their Changes

Abstract:

A theoretical paper proposes applications of golden proportion principles to physiological diagnostics. It outlines proposed metrics and discusses validation needs and limitations.

Osteoarthritis and Frailty: Associations, Relevance, and Counter Solutions

Abstract:

Many older adults, including those who have acquired painful disabling osteoarthritis of one or more joints may be frail rather than obese as is often reported. Those older adults who are frail may acquire osteoarthritis in turn if they encounter excess joint stresses and injury.

Evolution of the Solid Human Tumor Cells Properties in Various Experimental Systems in Vitro

Abstract:

Human malignant cell models which reflect the structural and physiological complexity of tumor tissue are of great importance for preclinical research in oncology. Spheroids/tumoroids derived from solid tumors are of great interest as cellular models mimicking the first vascular-free growth phase of a tumor node. The fact of the identity between artificially created tumor multicellular aggregates and the real tumor tissue, however, needs to be specified, described and validated in order to see how closely the spheroids are biologically similar to the malignized tissues in vivo compared to the monolayer cell cultures traditionally used. We present here a comparison study of the characteristics of solid tumor cells of different histogenesis (melanomas, soft tissue sarcomas and bone sarcomas,...