About Journal of Thyroid Cancer
A specialized peer-reviewed platform advancing thyroid cancer diagnosis, treatment, and survivorship through mechanistic, translational, and clinical research.
Journal Identity
ISSN: 2574-4496
DOI Prefix: 10.14302/issn.2574-4496
License: CC BY 4.0
Indexed open access journal
Editorial Scope
Thyroid carcinoma, endocrine oncology, surgical and medical management, molecular diagnostics, and survivorship care. We prioritize evidence that improves diagnosis and outcomes.
Publishing Model
Open access with single blind peer review. Rapid publication after acceptance with DOI registration and metadata validation included.
JTC curates research across mechanistic, translational, and clinical domains of thyroid cancer. Our scope encompasses molecular studies, diagnostic innovations, surgical outcomes, systemic therapies, and survivorship care that improve patient outcomes.
Molecular Genetics and Oncogenesis
Genetic mutations (BRAF, RAS, RET/PTC rearrangements), epigenetic modifications, chromosomal instability, and hereditary syndromes driving thyroid malignancy initiation.
Signaling Pathway Dysregulation
MAPK/ERK, PI3K/AKT/mTOR, Wnt/beta-catenin, and receptor tyrosine kinase pathways-mechanistic analysis of aberrant activation in thyroid carcinogenesis.
Tumor Microenvironment
Immune cell infiltration, fibroblast activation, extracellular matrix remodeling, and paracrine signaling networks influencing tumor progression.
Biomarker Discovery
Molecular markers for disease detection, subtype classification, prognostic stratification, and recurrence prediction with mechanistic rationale.
Cellular Metabolism
Altered glucose uptake, lipid metabolism, mitochondrial function, and metabolic reprogramming supporting thyroid cancer cell survival and proliferation.
Epithelial-Mesenchymal Transition
Molecular mechanisms of EMT induction, transcription factor regulation, and phenotypic plasticity enabling invasion and metastatic potential.
Angiogenesis and Vascular Biology
VEGF signaling, endothelial cell recruitment, and vascular network formation supporting tumor growth and dissemination.
Cell Cycle and Apoptosis
Checkpoint aberrations, cyclin/CDK imbalances, p53 pathway disruption, and resistance to programmed cell death in thyroid malignancies.
Experimental Models
Cell line characterization, patient-derived xenografts, organoid cultures, and CRISPR-engineered models replicating thyroid cancer biology.
Scope Alignment: JTC welcomes mechanistic studies, translational research linking molecular findings to clinical decisions, and clinical investigations that improve thyroid cancer diagnosis, treatment, and survivorship outcomes.
JTC publishes high-quality research across the full spectrum of thyroid cancer science and care:
- Identify novel molecular targets through genomic, transcriptomic, proteomic, and metabolomic profiling
- Elucidate signaling pathway crosstalk and feedback mechanisms
- Validate biomarkers through mechanistic studies demonstrating biological relevance
- Characterize tumor heterogeneity at single-cell resolution
- Investigate immune evasion strategies employed by thyroid cancer cells
- Map spatial biology using imaging mass spectrometry and spatial transcriptomics
- Develop computational models integrating multi-omic datasets
Original Research
Mechanistic studies with validated experimental approaches and reproducible findings.
Reviews
Comprehensive syntheses of molecular pathways and pathophysiological mechanisms.
Methods
Novel techniques for studying thyroid cancer biology at molecular resolution.
Short Communications
Rapid reports of significant mechanistic findings with preliminary data.
JTC maintains rigorous standards for mechanistic research. Submissions should demonstrate:
- Clear hypothesis with molecular or cellular focus
- Validated experimental models appropriate to the research question
- Reproducible methodology with appropriate controls
- Statistical rigor and transparent data presentation
- Mechanistic interpretation supported by evidence
- Data availability for key findings
Specialized Audience
Reach researchers focused on thyroid cancer molecular biology and pathophysiology.
Expert Review
Single blind peer review by specialists in molecular oncology and thyroid biology.
Open Access
Global visibility with CC BY 4.0 licensing for maximum research impact.
Rapid Publication
Average 18 days to first decision with 5-day publication after acceptance.
Submit Your Research to JTC
Share your thyroid cancer pathophysiology research with a specialized global audience.
