Aims and Scope
Journal of Thyroid Cancer advances molecular understanding of thyroid malignancies through rigorous pathophysiological research.
JTC curates research that illuminates how thyroid cancer works at the cellular and molecular level. Our scope encompasses mechanistic studies that identify disease pathways, validate biomarkers, and develop experimental models replicating thyroid cancer biology.
Molecular Genetics and Oncogenesis
Genetic mutations driving thyroid malignancy initiation and progression.
- BRAF, RAS, RET/PTC rearrangements
- Epigenetic modifications
- Chromosomal instability
- Hereditary syndromes (MEN2, Cowden)
Signaling Pathway Dysregulation
Mechanistic analysis of aberrant pathway activation in carcinogenesis.
- MAPK/ERK cascade
- PI3K/AKT/mTOR axis
- Wnt/beta-catenin signaling
- Receptor tyrosine kinases
Tumor Microenvironment
Stromal interactions influencing tumor progression and immune evasion.
- Immune cell infiltration
- Fibroblast activation
- Extracellular matrix remodeling
- Paracrine signaling networks
Biomarker Discovery
Molecular markers with mechanistic rationale for clinical translation.
- Disease detection markers
- Subtype classification
- Prognostic stratification
- Recurrence prediction
Cellular Metabolism
Metabolic reprogramming supporting cancer cell survival and proliferation.
- Altered glucose uptake
- Lipid metabolism changes
- Mitochondrial function
- Bioenergetic adaptations
Epithelial-Mesenchymal Transition
Molecular mechanisms enabling invasion and metastatic potential.
- EMT transcription factors
- Phenotypic plasticity
- Invasion pathways
- Metastatic colonization
Scope Clarity: JTC focuses exclusively on pathophysiology-the "how" and "why" of thyroid cancer at the molecular level. We do not publish clinical treatment protocols, patient management guidelines, surgical techniques, or therapeutic outcomes. Our editorial lens prioritizes mechanistic insight over clinical application.
Original Research
Mechanistic studies with validated experimental approaches (5,000-7,000 words)
Reviews
Comprehensive syntheses of molecular pathways (6,000-8,000 words)
Methods
Novel techniques for studying thyroid cancer biology (3,000-4,000 words)
Short Communications
Rapid reports of significant mechanistic findings (2,000-3,000 words)
JTC maintains rigorous standards for mechanistic research:
- Clear hypothesis with molecular or cellular focus
- Validated experimental models appropriate to the research question
- Reproducible methodology with appropriate controls
- Statistical rigor and transparent data presentation
- Mechanistic interpretation supported by evidence
- Data availability for key findings
Angiogenesis
VEGF signaling, endothelial recruitment, and vascular network formation supporting tumor growth.
Cell Cycle Dysregulation
Checkpoint aberrations, cyclin/CDK imbalances, and p53 pathway disruption in thyroid malignancies.
Experimental Models
Cell lines, patient-derived xenografts, organoids, and CRISPR-engineered systems.
Submit Your Research
Share your thyroid cancer pathophysiology research with a specialized global audience.
